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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF6
All Species:
53.94
Human Site:
S174
Identified Species:
84.76
UniProt:
P56537
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P56537
NP_002203.1
245
26599
S174
I
E
D
Q
D
E
L
S
S
L
L
Q
V
P
L
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_534401
245
26551
S174
I
E
D
Q
D
E
L
S
S
L
L
Q
V
P
L
Cat
Felis silvestris
Mouse
Mus musculus
O55135
245
26492
S174
I
E
D
Q
D
E
L
S
S
L
L
Q
V
P
L
Rat
Rattus norvegicus
NP_001032429
245
26553
S174
I
E
D
Q
D
E
L
S
S
L
L
Q
V
P
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001026019
245
26507
S174
I
E
D
Q
D
E
L
S
S
L
L
Q
V
P
L
Frog
Xenopus laevis
NP_001083080
245
26578
S174
I
E
D
Q
D
E
L
S
S
L
L
Q
V
P
L
Zebra Danio
Brachydanio rerio
NP_957238
245
26599
S174
I
E
D
Q
D
E
L
S
S
L
L
Q
V
P
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P56538
245
26476
S174
I
Q
D
Q
D
E
L
S
S
L
L
Q
V
P
L
Honey Bee
Apis mellifera
XP_392115
245
26312
S174
I
Q
D
Q
D
E
L
S
S
L
L
Q
V
P
L
Nematode Worm
Caenorhab. elegans
O62106
246
26289
A174
P
E
T
Q
R
E
I
A
A
L
L
Q
I
P
V
Sea Urchin
Strong. purpuratus
XP_785113
245
26286
S174
V
Q
E
Q
N
E
L
S
S
L
L
Q
V
P
L
Poplar Tree
Populus trichocarpa
XP_002310109
245
26349
S174
I
E
D
L
D
E
L
S
T
L
L
Q
V
P
L
Maize
Zea mays
NP_001148947
245
26554
S174
V
E
D
L
D
E
L
S
T
L
L
Q
V
P
L
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O22290
247
26492
A176
V
E
E
M
V
E
L
A
N
L
V
Q
V
P
L
Baker's Yeast
Sacchar. cerevisiae
Q12522
245
26439
S174
V
Q
D
Q
E
E
L
S
S
L
L
Q
V
P
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
N.A.
98.3
N.A.
97.9
98.7
N.A.
N.A.
93
92.2
91
N.A.
77.5
81.2
64.2
78.7
Protein Similarity:
100
N.A.
N.A.
99.1
N.A.
99.1
100
N.A.
N.A.
97.5
97.1
95.5
N.A.
89.8
91
80.4
90.6
P-Site Identity:
100
N.A.
N.A.
100
N.A.
100
100
N.A.
N.A.
100
100
100
N.A.
93.3
93.3
46.6
73.3
P-Site Similarity:
100
N.A.
N.A.
100
N.A.
100
100
N.A.
N.A.
100
100
100
N.A.
100
100
80
100
Percent
Protein Identity:
73.8
74.2
N.A.
58.7
72.2
N.A.
Protein Similarity:
84.4
83.6
N.A.
76.9
86.5
N.A.
P-Site Identity:
86.6
80
N.A.
53.3
80
N.A.
P-Site Similarity:
93.3
93.3
N.A.
86.6
100
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
14
7
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
80
0
74
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
74
14
0
7
100
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
67
0
0
0
0
0
7
0
0
0
0
0
7
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
14
0
0
94
0
0
100
94
0
0
0
94
% L
% Met:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
7
0
0
0
7
0
0
0
0
0
0
% N
% Pro:
7
0
0
0
0
0
0
0
0
0
0
0
0
100
0
% P
% Gln:
0
27
0
80
0
0
0
0
0
0
0
100
0
0
0
% Q
% Arg:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
87
74
0
0
0
0
0
0
% S
% Thr:
0
0
7
0
0
0
0
0
14
0
0
0
0
0
0
% T
% Val:
27
0
0
0
7
0
0
0
0
0
7
0
94
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _